Cier Sidebotham, 17, was reported missing from the Morley area yesterday.
She is believed to be with a male and there are concerns for her welfare.
A recent sighting of her was reported in the Scawsby area of Doncaster.
She is described as white, 5ft 7ins tall, and has brown hair with grey at the ends.
She was last seen waring a green ‘Gym King’ jumper, white vest top, black bottoms and black trainers, police said.
Anyone who has seen her or who has any information that could assist in tracing her is asked to contact Leeds District CID via 101 quoting log 664 of May 23.