Leodis Games based in Springfield Mills, Farsley, stayed open until 6am to welcome back keen gamers.
They were able to play war games and board games, as well as taking part in a Dungeons and Dragons game that had been specially tailored for the reopening event.
The lockdown has meant that gaming shops of this kind have not been able to open during the pandemic due to close contact.
Owner Neil Pritchard said that he was so excited to have customers back in store that he opened up as soon as the government allowed him to.
He added: "This last year has lead to a pent up desire to meet up and game in person.
"It's not just about people being able to enjoy themselves again, it's about the social contact and feeling like things are going back to normal.
"The hardest thing this last year has been seeing how many people have struggled with isolation and loneliness.
"Being able to game again is going to be a lifeline to many of our customers."
Leodis Games opened 2016.
Gamers can play the popular Warhammer 40,000 game in store, along with other licensed games from the Star Wars and Marvel universes.
The war games industry has seen a resurgence in lockdown and the main games supplier, Games Workshop, is now worth over £1bn on the stock exchange.
Leodis Games will return to gaming in store seven days a week following the event.
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