The brand, famed for its craft beer selection, already has a pub on Mill Hill, near Leeds Station, and a sister site in Headingley.
This is what our beer reviewer thought of Head of SteamThey're now believed to have taken on the lease of the former Lloyds Bank unit on Park Row and aim to open this summer.
The Head of Steam brand now has a presence across the country - there are pubs in Cardiff, Tynemouth, Sheffield, Newcastle, Nottingham, Liverpool, Hull, Durham, Manchester, Birmingham and Huddersfield.
The Mill Hill bar opened in 2014, replacing the old Spencer's pub after a takeover by north-east company Cameron's. The Head of Steam brand focuses on sites near railway stations.