Artists the Guerilla Girls will be producing work which will be shown on billboards across the country, including at Hyde Park Corner in Leeds
There will also be a website and online gig as part of their work 'The Male Graze'.
The festival, which has been running since 2015, is leaving London for the first time.
It is taking place from June 18 - July 18, and the Leeds element is being supported by The Tetley art gallery in Leeds city centre.
There will be films released on the festival's website for fans to watch and appreciate throughout the month-long event, with topics ranging from police brutality to dance mixed with poetry.
All films will be uploaded Tuesdays and Fridays on the official Art Night website at 8pm.
The festival does not have a theme this year, but is instead titled ‘Nothing compares 2 U’, after the Prince song made famous by Sinead O'Connor.
Artists have been told not to incorporate this message into their work but to allow it to set the tone for their work.
Helen Nisbet, Artistic Director of Art Night 2021, said “We are indebted to our artists for the time and the care they’ve put into making work under such uncertain and challenging circumstances.
"The constant change has been tough, but it has also offered a beautiful opportunity to adapt the format of the festival - to work across the whole country, to invite camaraderie through partnerships and to expand the duration of the festival.
"We’ve had to do some quick learning and shifting on considering what it means to curate and produce work to be viewed online but I’m excited about the scope of the commissions to be seen by anyone in the world with internet access”
Art Night was set up in 2015 by Philippine Nguyen and Ksenia Zemtsova.
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