The Whites head into the game in fine spirits, following their 3-1 win over Burnley last weekend.
The last time Leeds faced West Ham, back in September, David Moyes' side stunned their opponents at Elland Road, as they came from a goal down to win 2-1, with Michail Antonio scoring the winning goal in the 90th minute of the match.
Speaking ahead of the big cup tie against the Hammers, Leeds full-back Luke Ayling gave some insight into his views on being deployed in a more central role against Burnley, and said: “I enjoy playing centre-back to be honest.
“I grew up playing there for Arsenal as a kid, I spent my childhood playing there, then I got moved to right-back at Yeovil and have played there ever since.
“I love playing right-back and see myself playing there but I've played right-sided centre-half quite a lot in a three, which I really enjoy. If I get called upon to play centre-half whilst there's a lot of injuries, I don't mind doing it. I feel like I can do a job there, I enjoy it.”
He added: “I lead the way I've always led, even when skip's in the team. He's (Liam Cooper) around the place every day and he's still the leader around here, I'm just my happy self and get people up.
“It's vital he's (Marcelo Bielsa) here. He got us players who played in the Championship sitting ninth last year in the Premier League. Things haven't gone as to plan this year but I'm sure we can turn it around and get back to that form.”
Take a look at today's biggest stories from the Premier League, as the build-up to this weekend's third round action continues:
1. Magpies 'offered' Dieng
Newcastle United are said to have been offered the change to sign Marseille forward Bamba Dieng for around £12.5m. The Ligue 1 striker, who will represent Senegal at the Africa Cup of Nations, was sent off after six minutes in his side's last game before Christmas. (Sky Sports) Photo: SEBASTIEN BOZON
2. Conte eyes Perisic reunion
Spurs have been linked with a move for Inter winger Ivan Perisic. The experienced Croatia thrived under Antonio Conte during his time at the club, and has also played for the likes of Borussia Dortmund and Club Brugge. (Fussball Transfers) Photo: Francesco Pecoraro
3. Gunners flop linked with exit
Arsenal's £7m defender Pablo Mari has been tipped to leave the club this month, as he continues to struggle to break into the first team. He's made just three appearances this season, the last of which came back in September. (Sport Witness) Photo: Stuart MacFarlane
4. Hammers favourites to sign Barbosa
West Ham have been named favourites to win the race for Flamengo striker Gabriel Barbosa. The Brazil international, who has been hotly tipped to make a return to English football, has also been linked with Spurs. (Various) Photo: Wagner Meier
5. Raphinha wanted to replace Coman
Bayern Munich have been tipped to "cut ties" with their winger Kingsley Coman, with both Leeds United's Raphinha and Chelsea's Callum Hudson-Odoi said to be among their key targets. The former has scored eight league goals already this season. (L'Equipe) Photo: Jan Kruger
6. Magpies target keen to stay in England
Lazio and Juventus look to be out of the race to sign Liverpool striker Divock Origi, with the player said to be keen to remain in the Premier League. Newcastle and West Ham are both believed to be keen on the player, who could cost less than £10m. (Sky Sports) Photo: Marco Luzzani