Marcelo Bielsa's Whites stormed to a superb ninth-placed finish upon their top-flight return last season and their second term back in the country's top division will start with a trip to arch rivals Manchester United over the opening weekend of August 14.
A home clash against Everton is next on the agenda, followed by a trip to Burnley and then a home date against Liverpool.
Following the release of the new fixtures, we take a look at the Premier League' s betting market for the 2021-22 season and see where Leeds are ranked and on that basis where they are predicted to finish.
Our list runs in descending order, starting with the division's big outsiders. Who will go down?
1. 20th - Norwich City
Last season's Championship champions are the rank outsiders as they are 1500-1 to win the division with five different firms. The Canaries are evens favourites to go straight back down.
2. 19th - Watford
The Championship runners-up are 1500-1 with four different firms to win the division. The Hornets are 11-10 second favourites for the drop.
3. 18th - Southampton
Southampton are also 1500-1 to win the division but only with one firm and the Saints are as short as 200-1 elsewhere. Therein, the Saints are actually seventh favourites to go down at 5-1.
4. 17th - Crystal Palace
No Roy, no joy? Palace are 1000-1 to win the division with five different firms though as short as 250s. After the recently promoted trio, Palace are next in the relegation betting market, fourth favourites at 5-2 to go down.
5. 16th - Burnley
The Clarets are 1000-1 to win the division with five different bookmakers but are still expected to stick around for another season. The Clarets are joint fifth-favourites to go down at 37-13.
6. 15th - Brentford
Pontus Jansson and co's Championship play-off winners are far from the rank outsiders despite being 1000-1 to win the division with four different firms. That said, the Bees are actually third favourites for the drop at 24-19.