Here’s how the starting eleven is likely to look for the big game...
1. GK: Kiko Casilla
The Spaniard has atoned for his sending off against Sheffield United last month with three clean sheets on the bounce, and should start between the sticks again against Wigan. (Photo by Alex Burstow/Getty Images) Photo: Alex Burstow
2. RB: Luke Ayling
The former Bristol City man made his 100th appearance for United in last weekend's win over Sheffield Wednesday, and will look to continue his fine form against Wigan. (Photo by George Wood/Getty Images) Photo: George Wood
3. CB: Pontus Jansson
The Sweden international has been a force to be reckoned with in the Championship this season, and will need to be at the top of his game without Cooper alongside him. (Photo by George Wood/Getty Images) Photo: George Wood
4. CB: Gaetano Berardi
With Liam Cooper's chances of making the game still in doubt due to a muscular problem, Bielsa may look to rest his captain until Monday, and give Berardi the nod instead. (Photo by Daniel Smith/Getty Images) Photo: Daniel L Smith
5. LB: Ezgjan Alioski
The Macedonian marvel has been Bielsa's most used player this season for a reason, and will look to continue his excellent campaign with another tenacious outing. (Photo by Alex Livesey/Getty Images) Photo: Alex Livesey
6. DM: Kalvin Phillips
The academy product has continued to blossom at Elland Road this season, and will resume his usual role as the beating heart of United's side – screening the back four and enabling his teammates to burst forward at regular intervals. (Photo by Jordan Mansfield/Getty Images) Photo: Jordan Mansfield