Wharfedale crashed 41-15 in a tough opener at Macclesfield in National Two North.
Toms Asejevs scored an early converted try to give Wharfedale the lead, but first-half injuries to James Mehen and Ben Booth took their toll and they trailed at half-time.
Lewis Barker and Ryan Parkinson both scored a brace for the hosts and despite a second-half try from Jack Barnard and a penalty from Tom Barrett, it was Macclesfield who took maximum points in their first game after relegation from National One last season.
Huddersfield were unlucky to go down 44-36 at South Leicester, while Otley also lost out, 42-21 at home against Stourbridge. And Sheffield Tigers were beaten 38-5 at Dore Moor by Sedgley Park.
Ilkley were 20-16 winners over Kendal in the North Premier League with tries from scrum-half Jack Mapleston and flanker Joe Lowes, but they could have scored much more.
An injury-time try from Luke Edwards helped Harrogate win 21-20 at Billingham.
Three penalties from Luke White was all they could muster as Billingham led 20-9 early in the second half. But Olly Rosillo’s try was converted, and Edwards’ late effort snatched the win.
Elsewhere, Morley lost out 37-15 at home against Lymm, while Pocklington were beaten 48-3 at Wirral and Sandal lost 26-24 at home to Preston.
A hat-trick from Danny Booth was not enough to prevent West Leeds falling to a 28-26 defeat at Bridlington in North One East, the hosts fighting back from a 14-7 deficit at half-time.
Cleckheaton lost out 38-20 at Penrith, while Dinnington were beaten 28-19 at home against Percy Park and Malton and Norton were beaten 41-12 by hosts Northern.
Moortown ran in five tries as they won 31-16 over Selby in Yorkshire One, as did Hullensians who beat Bradford Salem 25-18.