Myler has been given the all-clear to resume playing after suffering two concussions in less than a month.
He missed the narrow losses to St Helens and Catalans Dragons and admitted he is desperate to get his boots back on in what is becoming a do-or-die situation for Rhinos.
“Having to miss games is annoying,” admitted the former England play-maker. “I hate missing games at the best of times and, obviously, we are going through a tough period at the minute with injuries and things.
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“I am the worst person to be watching rugby league so it’s good to be back in the fold. I’m looking forward to getting back out there.”
Myler confirmed he has fully recovered from blows to the head suffered away to Catalans last month and in the home clash with Huddersfield Giants three weeks ago.
“I’ve passed all the head assessments and I’m feeling good now,” he reported.
“You have to go through all the protocols and they decided I needed a two-week stand-down.
“I’d had two (head injuries) in three weeks. If you have two in 12 months you have to go and see a specialist, but I am all good now and sweet to play.”
Myler’s return will be a boost for Rhinos as they aim to avoid a club record seventh successive Betfred Super League defeat.
Wigan are second in the table, but were beaten 19-18 at Castleford Tigers six days ago and have won only one of their last five league and cup matches.
“It’s going to be tough,” predicted Myler.
“They are a bit hit and miss like us at the minute.
“They are lacking a bit of form, but they have got some players back from international duty and every time Leeds and Wigan play each other it’s going to be a big game.
“Playing there, it’s going to be a tough match. There wasn’t much in it when we played them (at Headingley) and we’re looking forward to it.
“We’ve got a few bodies back this week, which will be good and hopefully we’ll have a good crack.”
Rhinos will drop into the bottom-four if they lose tonight and Huddersfield - at Hull KR - and Catalans, away to Castleford Tigers, both win this weekend.
However, Myler reckons one win could turn their season around.
“We are doing it tough at the minute,” he admitted.
“We just need to stick together and keep working hard and obviously it will turn for us at some point.”
Rhinos have lost four games by a drop goal this year and only three points separated the teams when they were beaten by Catalans eight days ago.
Had they won those games - and the draw at Huddersfield - Leeds would be second in the table.
Myler admitted the narrow nature of most of their defeats is both disappointing and encouraging.
He said: “It shows how close we are at times, but obviously we are still getting beaten.
“We can turn that around. We aren’t too far off, but we are running out of games.
“Nobody wants to be in the middle-eights, but we’re not focusing on that.
“We’re just focusing on Wigan, it’s a big, tough test we’ve got and we’ll stick together and keep working hard and hopefully it will turn around for us.”