Leeds’ squad is their strongest of the season, with only Stevie Ward - who has not played this year - ruled out due to injury.
McGuire missed Rhinos’ final three games in Super League due to a foot injury, but has been included in their initial 19-man squad for the middle-eights opener.
Brett Delaney is back in contention following illness and Joel Moon could return after a knee problem, with Jordan Lilley dropping out from the team which won at Hull KR two weeks ago.
Lilley has played on dual-registration for Rovers this season, but is not included in their initial squad for Saturday.
Rhinos’ 19 includes Ashton Golding, who was a dual-registered player in the Rovers team which beat Bradford Bulls two weeks ago to seal a place in the Qualifiers.
Anthony Mullally – another Leeds player – also drops out from Rovers’ squad.
On-loan Leeds trio Jordan Baldwinson, Luke Briscoe and Josh Walters are set to play against their parent club.
Walters is available after injury and ex-Rhinos winger James Duckworth also comes into contention, along with Danny Craven - who has recovered from a hamstring problem - and Luke Cooper.
Rovers’ 19 includes forward Jack Ormondroyd, who will join Rhinos last year, as well as ex-Leeds players Kyle Briggs and Darrell Griffin, along with Ian Hardman, who works for Rhinos’ Foundation.
The 19-man squads are:
Rovers: Ellis, Duckworth, Tagg, L Briscoe, Ormondroyd, Thackeray, Channing, Griffin, Briggs, Hardman, Davies, Craven, Bostock, Cooper, Snitch, Baldwinson, Taulapapa, Spears, Walters.
Rhinos: T Briscoe, Watkins, Moon, Hall, McGuire, Burrow, Galloway, Cuthbertson, Jones-Buchanan, Ablett, Sutcliffe, Delaney, Singleton, Garbutt, Keinhorst, Achurch, Golding, Ferres, Segeyaro.