Leeds Rhinos will be at home to lower division Leigh Centurions in the quarter-finals of the Tetley’s Challenge Cup next month.
Castleford Tigers - who are second, behind Leeds, in Super League - face a tough trip to Cup holders Wigan Warriors.
The other ties see Bradford Bulls play host to Warrington Wolves and Kingstone Press Championship outfit Keighley Cougars travel to Widnes Vikings.
Leigh are currently top of the Championship, having won won their eight games so far. They saw off Featherstone Rovers 26-16 in the fifth round.
Ironically, the last time Leeds drew a team from outside Super League in the Challenge Cup was for a quarter-final tie in 2012, when they won 60-12 at Leigh.
Leeds boss Brian McDermott said: “We have too much respect for Leigh - and the competition - to take them lightly.”
Tigers will travel to DW Stadium in confident mood having won their last two meetings with Wigan, including a thrilling 36-31 success at MAH Jungle last month.
Cas coach Daryl Powell said: “It is a tough game, but if you are going to win something you have to play in tough games.”
Two quarter-final ties will be televised by the BBC. Sky Sports have an option to broadcast the remaining matches.
The sixth round will be played on the weekend of June 7 and 8.