With eight players ruled out and a doubt over one more, Rhinos have called 17-year-old England academy loose-forward Cameron Smith into their initial 19-man squad.
McGuire suffered knee damage in Rhinos’ opening game of the season, two months ago and his comeback was delayed by a calf injury sustained in training, but he has played in their last two matches.
Brett Delaney (hamstring) could return on Friday is he passes a fitness test. Jimmy Keinhorst (calf) is also back in contention, but Ryan Hall (ankle), Tom Briscoe (shoulder), Joel Moon (groin), Adam Cuthbertson (biceps), Stevie Ward (knee), Josh Walters (ankle) and Brett Ferres (calf) remain on the casualty list.
Hull coach Lee Radford will select from the 17 who beat Huddersfield Giants last week, plus Leon Pryce and Danny Washbrook.
Gareth Ellis and Mark Minichiello remain sidelined, along with Carlos Tuimavave, who suffered a groin injury in last week’s warm-up.
Leeds Rhinos’ initial 19 is: Hardaker, Watkins, Burrow, Galloway, Falloon, Jones-Buchanan, Ablett, Sutcliffe, Delaney, Singleton, Garbutt, Keinhorst, Achurch, Mullally, Handley, Golding, Baldwinson, Lilley, Smith.
Hull’s initial 19 is: owden, Fonua, Green, Hadley, Houghton, Manu, Michaels, Naughton, Palea’aesina, Pritchard, Pryce, Shaul, Sneyd, Talanoa, Taylor, Thompson, Watts, Washbrook, Yeaman.