Former Leeds boss Garry Monk will return to Elland Road with his new Middlesbrough side on Saturday, November 18.
Monk resigned as Leeds boss in May despite the offer of a one-year contract extension having guided the club to seventh place in the Championship last season.
He took over at Middlesbrough last month as the permanent replacement for Aitor Karanka, following a spell of temporary control under Steve Agnew.
Monk's return to Elland Road falls straight after the Autumn international break and will be Leeds' only home game of the month.
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Leeds will visit the Riverside in the reverse fixture on Saturday, March 3.
Both meetings come are sandwiched between games against Brentford and Wolves.
Leeds played out a goalless draw in their previous meeting with Boro at Elland Road in February 2016.