Whites head coach Marcelo Bielsa has been dealing with a whole host of injuries of late but the Whites are approaching the contest following back-to-back league wins, the 3-1 success at home to Burnley over new year followed by last weekend's fine 3-2 triumph at West Ham United.
Pascal Struijk returned from a foot injury to start at the London Stadium but Bielsa had nine players injured for the contest plus Diego Llorente suspended.
Leeds then lost both Junior Firpo and Adam Forshaw to muscular injuries just after the 20-minute marker.
Young duo Leo Hjelde and Lewis Bate were brought on as replacements and Bielsa then introduced record signing Rodrigo after the break, the Spaniard re-appearing following a six-week lay off due to bilateral heel pain.
Bielsa then revealed at Thursday's pre-match press conference that he would probably be able to welcome back both Joe Gelhardt and Tyler Roberts from injury into his squad for this weekend's clash against the Magpies, in addition to the returning Rodrigo.
Llorente is also back available after serving a one-match ban - in effect giving Bielsa a quadruple team news boost in addition to the returns of Rodrigo, Gelhardt and Roberts.
However, United's head coach has also revealed that Patrick Bamford has a new injury - an issue at the bottom of the foot - and the Whites no 9 joins Kalvin Phillips, Liam Cooper, Jamie Shackleton, Sam Greenwood and Charlie Cresswell on the sidelines.
Firpo and Forshaw are also injured whilst Stuart McKinstry and Archie Gray picked up knocks playing for United's under-23s on Monday night.
Crysencio Summerville had also recently hurt his clavicle.
Leeds would put themselves 13 points clear of the Magpies with a victory and this is how the Whites might end up lining up.
Leeds then lost both Junior Firpo and Adam Forshaw to muscular injuries just after the 20-minute marker.
7. CM - Mateusz Klich
The Pole was denied a second league goal of the season in the victory at West Ham by another confusing VAR call but Klich is building up a consistent run of starts and another one surely awaits in the middle of the park.
8. ACM - Rodrigo
The record signing returned as a second-half substitute against the Irons and Bielsa must now decide whether to start him or bring Rodrigo along gradually from the bench. If it's the bench then Hjelde or Lewis Bate could start, perhaps with Klich at no 10.
9. RW - Raphinha
The Brazilian caused mayhem down the right flank at the London Stadium and Bielsa admitted himself last week that that Brazilian international is United's best player. A special talent.
10. LW - Jack Harrison
Harrison has gone from not scoring in his first 15 league games this season to netting four in his last two, the winger bagging a brilliant hat-trick at West Ham. Automatic pick on the left flank when in such fine form.
11. ST - Dan James
Bielsa will probably have both Joe Gelhardt and Tyler Roberts back available but it might well be that the duo are on the bench after their recent injuries. That would mean either James or Rodrigo upfront and James is often deployed there at present.