Head coach Marcelo Bielsa has two main new injury concerns but also one Whites star back available to return to the fold.
Lee Sobot takes a look at a predicted line-up for the clash against Monday night's visitors.
1. Illan Meslier (GK)
Has been away with France's under-21s and being kept out there by Alban Lafont but the already undisputed Whites no 1 will be back for still only his 16th Whites start. Photo by MOLLY DARLINGTON/POOL/AFP via Getty Images.
2. Luke Ayling (RB)
Says he is fully prepared to switch to centre-back if needed with Diego Llorente out through injury and captain Liam Cooper a doubt but other options mean Ayling ought to stay at right-back. Photo by Catherine Ivill/Getty Images.
3. Robin Koch (CB)
Has settled in very quickly at Leeds and all set to return from international duty with Germany to make his fifth start for the Whites at the heart of the defence but possibly without Liam Cooper by his side. Photo by Catherine Ivill/Getty Images.
4. Pascal Struijk (CB)
United's young fourth choice centre-back has excelled when called on. Bielsa says Cooper is at risk of missing out with a groin injury and with Llorente out Struijk could well partner Koch. Photo by SHAUN BOTTERILL/POOL/AFP via Getty Images.
5. Stuart Dallas (LB)
The versatile Northern Ireland international has been United's firm first choice left back for some time and is now set to come up against the lightning fast but also powerful Adama Traore down that flank. Photo by Catherine Ivill/Getty Images
6. Kalvin Phillips (CDM)
What a two months, from a first England call-up to three starts and four caps. Will now find himself back in his ideal role as a deep sitting holding midfielder on his own as opposed to being part of a double pivot. Photo by Paul Ellis - Pool/Getty Images.