Both sides are still seeking their first victory of the 2021-22 top-flight campaign and Leeds will be looking to bounce back from Sunday's 3-0 reverse at home to Liverpool.
The Whites lost Diego Llorente to injury against the Reds as part of a contest in which fellow centre-back Pascal Struijk was shown a straight red card, for which he is now serving a three-game ban.
Another centre back, Robin Koch, has also been out injured with a pelvic issue whilst Adam Forshaw missed the Liverpool game with a muscular injury.
Whites head coach Marcelo Bielsa confirmed at Thursday's pre-match press conference that Forshaw, Koch and Llorente would all miss the trip to St James' Park, in addition to the banned Struijk, and this is how we think the Whites will line up.
Another centre back, Robin Koch, has also been out injured with a pelvic issue whilst Adam Forshaw missed the Liverpool game with a muscular injury.
17. Sub - Tyler Roberts
The Wales international replaced Rodrigo in the no 10 role at the interval of Sunday's clash against Liverpool but the bench seems likely again given Bielsa's words on Rodrigo at his pre-match press conference.
18. Sub - Crysencio Summerville
It's take your pick from the likes of talented youngsters Crysencio Summerville, Joe Gelhardt or Sam Greenwood for the bench. Perhaps winger Summerville will get the nod although Bielsa has named Liam McCarron in his 18 for the last two league games.