The last time the two side's met, back in January, Spurs triumphed 3-0, and the Whites will be out for revenge this time out as they look to move back into the top half of the Premier League table.
Speaking after last weekend's loss on the south coast, ex-Leeds goalkeeper Paul Robinson claimed the Whites are yet to "fill the void" left by star loanee Ben White returning to the Seagulls last summer, and said: “They do miss him whether it's offensively or defensively.
“I think Bielsa has developed him, made him into a better player and they do struggle when he is not there because yes he is destructive and he breaks play down but he's also offensive and he can set attacks going and they do miss him.
“Last year they had a problem at the start of the season when he didn't play when they won the Championship and Ben White filled that void. Since he has left I don't feel Leeds have a direct replacement for him.
“Pascal Struijk has played there, we saw Robin Koch play there as well today. But neither have been able to have the same effect that Kalvin (Phillips) does on the game.”
Here are today's biggest transfer stories and the latest team news involving Leeds United and the rest of the Premier League, as the build-up to this weekend's action continues:
“I think Bielsa has developed him, made him into a better player and they do struggle when he is not there because yes he is destructive and he breaks play down but he's also offensive and he can set attacks going and they do miss him.
7. Magpies handed Ajer boost
Sources close to Norwich City have suggested that the club could be priced out of a move for Celtic defender Kristoffer Ajer, opening the door for Newcastle United to swoop in. However, they're likely to still haggle down the £25m asking price. (Eastern Daily Press) Photo: VINCENZO PINTO
8. Toffees keeping tabs on Bales
Real Madrid outcast Gareth Bale has emerged as a transfer target for Everton this summer. The Wales international is showing signs of getting back to his best on loan with Spurs, and scored a hat-trick against Sheffield United last weekend. (Daily Star) Photo: Shaun Botterill
9. Gunners to challenge Leeds for Kamara
Arsenal have been tipped to rival Leeds United for Rangers midfielder Glen Kamara this summer. The £12m-rated ace came through the Gunners' youth academy, but never played a single game for the club before he was released. (Football Insider) Photo: Ian MacNicol
10. Man Utd lead Sancho race
Ahead of a busy summer transfer window, Man Utd have been named favourites to sign Borussia Dortmund winger Jadon Sancho, ahead of Chelsea. He's scored six goals and provided nine assists in the league this season. (SkyBet) Photo: INA FASSBENDER