The last time the two side's met, back in January, Spurs triumphed 3-0, and the Whites will be out for revenge this time out as they look to move back into the top half of the Premier League table.
Speaking after last weekend's loss on the south coast, ex-Leeds goalkeeper Paul Robinson claimed the Whites are yet to "fill the void" left by star loanee Ben White returning to the Seagulls last summer, and said: “They do miss him whether it's offensively or defensively.
“I think Bielsa has developed him, made him into a better player and they do struggle when he is not there because yes he is destructive and he breaks play down but he's also offensive and he can set attacks going and they do miss him.
“Last year they had a problem at the start of the season when he didn't play when they won the Championship and Ben White filled that void. Since he has left I don't feel Leeds have a direct replacement for him.
“Pascal Struijk has played there, we saw Robin Koch play there as well today. But neither have been able to have the same effect that Kalvin (Phillips) does on the game.”
Here are today's biggest transfer stories and the latest team news involving Leeds United and the rest of the Premier League, as the build-up to this weekend's action continues:
1. Mourinho lands new management role
Ex-Spurs, Chelsea and Manchester United boss Jose Mourinho has moved quickly to take up a new job in management following his Spurs exit, and will take over as Roma manager in time for the start of next season. (Club website) Photo: CLIVE BRUNSKILL
2. Toffees favourites to land Toney
Everton have been named as the early favourites to sign Brentford sensation Ivan Toney this summer. Leicester City and Brighton & Hove Albion also look to be in the running to land the 30-goal star striker (Oddchecker) Photo: Justin Setterfield
3. BVB could keep Haaland
Borussia Dortmund striker Erling Haaland, who has been linked with the likes of Man City and Chelsea, could be set to stay with his club for another season, with the club's CEO insisting they're determined to hold onto the player. (Metro) Photo: RONNY HARTMANN
4. Hammers ready Johnstone raid
West Ham United are believed to be leading the race to sign West Bromwich Albion goalkeeper Sam Johnstone. The £18m-rated stopper is also the respective radars of Man Utd and Spurs. (ESPN) Photo: Pool
5. Burnley keen on Christie
Norwich City and Burnley have both been tipped to chase Celtic midfielder Ryan Christie, whose contract bizarrely expires next January rather than in the summer. He's also been linked with Southampton and Arsenal. (Daily Mail) Photo: Mark Runnacles
6. Blades-linked boss addresses speculation
KV Oostende boss Alexander Blessin has again batted away suggestions he could become Chris Wilder's successor at Sheffield United, insisting he's fully focused on his side's league campaign and pointing out he still has a year left on his contract. (The Star) Photo: VIRGINIE LEFOUR