M621 in Leeds not expected to reopen for two hours with delays of up to 90 minutes after crash
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West Yorkshire Police said the M621 is closed at Junction 3 to Junction 4 on the clockwise carriageway as the force deal with an incident.
A male pedestrian was taken to hospital in a critical condition following the 5am crash.
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Hide AdHighways England have now confirmed new details of when the road closure is expected to be lifted.
They said: "We now have an estimated time for reopening.
"We are looking to have the road open in 2 hours."
Motorists have described delays across the city, with the city centre gridlocked.
First West Yorks tweeted: "All Services are encountering severe delays.
"All arterial routes extremely busy particularly in Holbeck / Beeston due to closure on M621 Westbound.
"Delays now up to 80 minutes late on some journeys."
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Hide AdA statement from West Yorkshire Police said: "Police were called at around 5.00am to reports of a road traffic collision involving a pedestrian and a vehicle on the M621.
"The male pedestrian has been taken to hospital in a critical condition.
"The M621 clockwise is closed between junction 3 and junction 4.
"Please find an alternative route."