Rolling road closures were in place as the marchers made their way around the city centre.
Protests are taking place across the UK as part of the 'Worldwide Rally for Freedom'.
An post for the Leeds march on social media reads: "Together we are free
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"We are taking a stand against the government lies, vaccinating our children and opposition to vaccine passports."
First Bus tweeted: "A protest is scheduled to take place in Leeds City Centre today from 13:00 at Millennium Square. Rolling road blocks will be in place and this is likely to cause disruption to services.
"Please allow additional travel time where possible."
Freedom Rally taking place in Leeds city centre with road closures and bus delays expected
Last updated: Saturday, 18 September, 2021, 15:46