She has helped raise more than £50m for good causes in her role as chief executive of the Leeds Community Foundation.
Now, though, Sally-Anne Greenfield is seeking a new challenge and has announced that she is leaving the charity, which she set up from her living room in 2004.
She will stay in her post until early next year before moving into a consultancy role that will make her skills available to a wide range of businesses and third sector organisations.
Sally-Anne, who was recently awarded an honorary doctorate by Leeds Beckett University, said: “I’m immensely proud of our achievements and seeing how much LCF has grown.
“It has been a privilege to lead the Foundation in its work to help improve the lives of thousands of people in the communities of Leeds – some in ways that have been life changing, others in terms of practical, everyday support.
“It has been a fantastic experience working with a very dedicated team of trustees who have given up their time, freely, to guide the Foundation forward.
“It’s also been a real pleasure to work with an incredibly talented team of staff who bring endless passion and enthusiasm to their roles.
“I will watch the continued growth and success of LCF with great interest.”
Sally-Anne’s tenure as chief executive has seen the Foundation distributing more than £33m in grants designed to make a positive difference to areas that need it the most.
Notable achievements include the success of the Leeds Flood Appeal, which raised funds to deal with the damage caused by Storm Eva on Boxing Day 2015.
The Foundation has also managed the arts education fund established in memory of murdered Leeds schoolteacher Ann Maguire.
And, in 2013, it teamed up with the Yorkshire Evening Post to run the Winter Warmth Campaign, which raised tens of thousands of pounds for groups working with the elderly and other vulnerable people during cold weather.
The charity has also been involved in much-praised community projects such as the transformation of the old Gipton Fire Station building and the construction of a new home for Leeds Mencap in East End Park.
High-profile events organised by the Foundation in recent times have included Leeds Leads: Encouraging Happy Young Minds.
Held in July in the city centre, the event brought together mental health projects that have received support from the charity’s Leeds Fund programme.
And it made headlines around the world thanks to one particularly special attendee in the shape of Prince Harry.
Speaking on the day, Sally-Anne said: “He was utterly charming and really engaged and spent lots of time speaking to some of the community groups we’ve funded.
“We think [the visit] is really important for the city because it has helped raise the profile of mental health in Leeds.
“We’ve been trending on Twitter and it’s good to explain to people that there is support out there.”
Praise for Sally-Anne’s efforts was led today by Foundation chair Rachel Hannan.
She said: “Her hard work and dedication over the years has contributed hugely to the development of a very special organisation, which does much to help improve the lives of many in our city.”
The Foundation said the process of recruiting Sally-Anne’s successor would start shortly.