Work on New Briggate started in July 2021, after a wider consultation in 2018 around improving bus routes, cycle lanes and footways in the city centre.
The work, which forms part of Leeds City Council's £173m Connecting Leeds programme, now sees motor traffic removed from the road completely except for loading times.
The council also says the scheme will reduce city centre congestion and help to improve air quality.
It follows on from work on areas around Leeds Corn Exchange, including highway improvements and a creation of a new public space.
Connecting Leeds aims to tackle the climate emergency in Leeds whilst delivering on Council objectives of delivering inclusive growth and improving the health and well-being of Leeds residents.
Coun Helen Hayden, Leeds City Council’s executive member for infrastructure and climate, said: “We are delighted another major step in city centre improvements is now complete.
"The work seen here will help to attract investment to New Briggate and offer more leisure options whilst improving active travel routes for people using the city. We would like to thank businesses; bus operators and users; and the public for their patience whilst construction has been carried out.”