Nathan Popple, who has severe disabilities due to cerebral palsy, claims to have been quoted £108 for a one-way trip in a wheelchair accessible car for a 5.6 mile journey from his Adel home to Armley.
The 18-year-old is behind the Accessible Leeds website, which rates services in the city on how they cater for disabled people.
The quote came after his wheelchair accessible car became unusable after an accident.
Lamborghini pictured with car on top of its bonnet at busy Leeds junction following crash
Rage Against The Machine pull out of headline slot at Leeds Festival
Leeds thunderstorms warning as Met Office shares latest weather forecast
Leeds Bradford Airport: Full statement on August security staff strike
Woman "turned blind eye" to drug dealing at her home, Leeds Crown Court told
He claims to have been rejected travel by private hire drivers in Leeds, while drivers of Hackney carriages, or black cabs, often fail to stop for him or refuse to help him in or out of their vehicles.
In a letter of complaint sent to operators, MPs and Leeds City Council leaders, he said major firms in the city “treat disabled people as second-class citizens”.
He continued: “Complaints about these companies need to be taken seriously and real action needs to be taken against them.
“At the minute Leeds feels like a no-go area for disabled people.”
Mr Popple said that despite many private hire firms advertising that their vehicles are wheelchair accessible, prices are “awful” for disabled people.
He claims other private hire firms offered the Adel to Armley return trip for £60 or £30 but offered either limited times or refused advanced bookings.
“There are endless stories of taxis not showing up, driving away or refusing to stop for disabled people, refusing to state a collection time or simply overcharging,” he said.
“Disabled people have a massive amount to give to our communities and to our city. I am not asking for special treatment, I am asking for fairness.”
A spokeswoman for Leeds City Council said: “We are always very concerned to hear about taxi and private hire drivers in Leeds who do not treat all passengers equally and will be investigating Mr Popple’s complaints.”
She explained that all new taxi or private hire licence applicants receive customer care training that emphasises fair treatment for all, although the council has no control over charges levied.
The council can revoke private hire licences if complaints are received and proven. Hackney carriage drivers must also abide by the Equality Act 2010 or face possible prosecution.
Neither the Leeds Private Hire Drivers Association nor Unite the Union’s Leeds Hackney carriage branch were available to comment when contacted by Yorkshire Post Newspapers.