Harehills Lane is shut after an accident on Tuesday afternoon.
Images from the scene show fire crews working to free at least one person from a Volvo estate car.
West Yorkshire Fire and Rescue Service Tweeted that four vehicles were involved.
Debris from the vehicles are strewn across the road.
Harehills Lane is closed between Compton Road and Strathmore View while emergency services work at the scene.
Passer-by Carolyn Kerfoot took these photos of the rescue.
More to follow.