Officers have closed the A660 Otley Road in Adel.
Police were called by the ambulance service at 10.54am to reports of a two-vehicle crash between a motorcylist and a Silver Ford Van.
The motorcyclist was injured in the crash and taken to hospital.
The motorcylist's injuries are not thought to be life threatening.
Traffic is building in the surrounding area, with a police cordon set up by emergency services at the scene.
The road remains closed.