John Worboys has been charged with drugging four alleged victims with the intent of committing sex crimes.
The 62-year-old black taxi driver, of HMP Wakefield, is set to appear at Westminster Magistrates' Court on May 23.
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Now known as John Radford, he faces two counts of administering a stupefying or overpowering drug with intent to commit rape or indecent assault, and two of administering a substance with intent to commit a sexual offence.
The alleged crimes are said to have taken place between 2000 and 2008 in London.
A Crown Prosecution Service (CPS) spokesman said: "In September 2018, the Crown Prosecution Service received a file of evidence from the Metropolitan Police relating to allegations of non-recent sexual assault and of administering drugs to cause unconsciousness.
"Following a review of the evidence, the CPS has today charged John Radford, formerly known as John Worboys, with four offences."
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The charges concern four individuals and relate to allegations made to police in early 2018.