Whites head coach Marcelo Bielsa named an unchanged side for Saturday's 3-0 win at home to Fulham, for which Pablo Hernandez and Barry Douglas returned from injury as second-half substitutes.
But how will Leeds line up against the Hatters? Lee Sobot takes a look at a predicted line up.
1. Illan Meslier (GK)
Another clean sheet against Fulham and all set to look to continue his progress in goal with Kiko Casilla still banned. Picture by Simon Hulme.
2. Luke Ayling (RB)
One of those to have really led the physical battle against Fulham and appears a certainty for the right back role. Picture by Simon Hulme.
3. Liam Cooper (CB)
United's captain who is leading from the front at centre-back alongside Ben White and will now look to keep Luton's Irish international striker James Collins quiet. Picture by Bruce Rollinson.
4. Ben White (CB)
The Brighton loanee has still played every minute of every Leeds league game this season and White excelled against Fulham, thriving despite being elbowed in the face by Aleksandar Mitrovic early doors. Picture by Jonathan Gawthorpe.
5. Stuart Dallas (LB)
Continually impressing, wherever you play him, but the left back slot has become the Northern Ireland international's own of late. Picture by Jonathan Gawthorpe.
6. Kalvin Phillips (CDM)
Much better from the Yorkshire Pirlo against Fulham and Phillips will be eyeing another strong display against the Hatters in the holding midfield role. Picture by Tony Johnson.