Southampton v Leeds United team news: Kiko Casilla starts as Marcelo Bielsa makes three changes
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Illan Meslier and Pascal Struijk both drop to the bench whilst Matuesz Klich is absent along with Robin Koch having been granted early leave by Bielsa with this summer's Euros in mind.
Koch is also carrying a slight knock.
Casilla starts just his second Premier League game of the season and first since January having played the full match of the 1-0 loss at home to Brighton for which Meslier was ill.
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Hide AdCooper is back having been an unused substitute in Saturday's 4-0 win at Burnley whilst record signing Rodrigo starts for the first time since returning from a muscular injury.
Helder Costa is out for the rest of the season with a back injury whilst Adam Forshaw also remains out.
Youngster Joe Gelhardt has been recovering from a minor niggle and is still missing but Pablo Hernandez returns from injury to the bench.
Southampton: McCarthy, Walker-Peters, Stephens, Vestergaard, Salisu, Ward-Prowse [c], Armstrong, Djenepo, Tella, Adams, Walcott. Subs: Forster, Bednarek, Diallo, Ferry, Minamino, Redmond, Obafemi, Nlundulu, Ings.
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Leeds United: Casilla, Ayling, Cooper, Llorente, Alioski, Phillips, Dallas, Harrison, Rodrigo, Raphinha, Bamford. Subs: Meslier, Struijk, Davis, Berardi, Jenkins, Shackleton, Roberts, Poveda, Hernandez.