A forensics firm, which has laboratories in Wakefield and Leeds, is axing up to 170 jobs.
LGC, which has worked on the cases of Rachel Nickell and Damilola Taylor, is axing dozens of jobs after “unprecedented change” in the market.
The firm, which is based in Middlesex, will see jobs slashed from eight sites across the UK.
Nearly half of the company’s 200 posts in Oxfordshire are currently being reviewed.
Spokeswoman Guenaelle Holloway said LGC would be “streamlined and simplified” to make it more cost-effective.
Ms Holloway said: “The change programme will focus LGC on fewer specialist sites, creating bigger, more flexible teams; reshape our team structures to meet the skills mix required by changing customer needs; and reduce the total workforce by approximately 150-170 full-time employees.
“For those employees whose jobs may be at risk, this will be a difficult time.”
A 90-day consultation period is under way.